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Introduction
Head & neck cancer treatment and diagnosis
Head & neck cancer
Head and neck cancers are a varied group of cancers that begin in the head or neck, typically defined as the tissues above the clavicle, but excluding skin, brain and cranial nerves, and thyroid/parathyroid. Head and neck cancers account for roughly 4% of all cancers in the United States.
Early diagnosis and advancements in treatment have enhanced the chance of survival and better cosmetic and functional outcomes.
What is head and neck cancer?
Chapter 1
What is head and neck cancer?
Cancers of the head and neck can begin in the:
- Oral cavity, which includes the inner surface of the lips, front area of the tongue, gums, lining of the cheeks and lips, bottom and top of the mouth, and the area of gum behind the wisdom teeth
- Paranasal sinuses and nasal cavity
- Nasopharynx (the upper part of the pharynx, or throat)
- Hypopharynx (the lower part of the pharynx, or throat)
- Salivary glands
- Supraglottic larynx (above the vocal cords)
- Larynx (vocal cords)
- Subglottic (below the vocal cords)
Head and neck cancers are designated in the location they start in. The most common types of head and neck cancer in the US are mouth (oral cavity) and larynx (the vocal cords).
Risk factors for head and neck cancer
The following factors may increase your risk of developing head and neck cancer:
- Excessive amounts of alcohol
- Smoking tobacco products, including cigarettes and chewing tobacco (the impact of vaping/e-cigarettes on head and neck cancers is not yet clear)
- Being male over the age of 50
- Having a compromised immune system
- A family history of head and neck cancer
- Being unvaccinated for human papillomavirus (HPV)
- Practicing poor oral hygiene or not regularly cleaning dentures, especially ill-fitting dentures
- A job in which you are exposed to certain substances, such as wood dust, formaldehyde, nickel dust or asbestos
- Certain genetic disorders, such as Fanconi anemia and dyskeratosis congenita
- Certain viral infections, including:
- Epstein-Barr virus
- Hepatitis C virus
- Herpes simplex virus
- HPV
- Improper management of gastroesophageal reflex disease (GERD)
- Previous radiation therapy to the head or neck
- A diet that is nutritionally deficient, especially low in fruits and vegetables and high in salt-cured fish and meat
The combination of alcohol and tobacco use significantly increases your risk.
Having a risk factor for head and neck cancer doesn’t mean that you will definitely get it, but it makes you more likely than someone without the risk factor. Speak to your healthcare provider about your individual risk factors.
Symptoms of head and neck cancer
The signs and symptoms of head and neck cancer vary depending on where they begin; they can include:
- Sore in the mouth or throat that doesn’t heal despite conservative management
- Jaw swelling
- Unusual oral, nasal or throat bleeding
- Foul breath not caused by poor dental hygiene
- Change or hoarseness of voice
- Chronic (long-term) sinus infections
- Frequent headaches, pain or swelling around the eyes or double vision
- Lump in the neck
- Difficulty or pain when swallowing
- White, reddish, or ulcerated patch on gums, tongue or inside of the mouth
- A feeling like something is constantly stuck in your throat
- Pain in your face, head or throat that won’t go away
- Trouble breathing or speaking
- Trouble hearing or ringing in the ears
- Consistent nose bleeds or unusual nasal discharge
- Unexplained numbness or feeling of weakness
- Dentures no longer fit
- Unexplained weight loss
- Persistent fatigue
Having symptoms for head and neck cancer doesn’t mean that you have it. Speak to your healthcare provider if you have any concerns and are experiencing any of the above symptoms.
Causes of head and neck cancer
Mutations (changes) in cells from a variety of external or genetic factors cause them to become cancerous and multiply rapidly. Being exposed to certain substances (such as workplace chemicals or nicotine), having certain infections or having other factors listed as risk factors above can cause head and neck cancer.
Screenings for head and neck cancer
Screening is a test that helps detect the very early stages or risk factors present for a specific health condition, ideally before a person shows any symptoms. Currently, there is no scientific evidence showing the benefit of screening for head and neck cancer. If you have any of the factors listed above as risk factors, you should see your healthcare provider.
It is recommended that you attend annual appointments with your primary care provider who should carefully examine all areas of the inside and outside of your mouth, nose, nasal passages, head and neck for signs of problems. Additionally, it is important you visit your dentist for routine cleanings and examinations. During these appointments, your dentist will check your neck and mouth for any concerning symptoms.
Diagnostics
Chapter 2
Diagnostics
Your healthcare provider may use some combination of the following tests to diagnose your head and neck cancer:
- Physical examination. Your healthcare provider will examine your head and neck for abnormalities. They will also likely ask you questions about your health history and symptoms related to head and neck cancer.
- Biopsy. During this test, a small tissue sample (biopsy) is removed and sent to the laboratory for close analysis. Pathologists inspect the biopsy under a microscope for any signs of cancer.
- Blood test. You might have blood tests to check your general health or help your doctor diagnose what is causing any symptoms you have.
- Endoscopy. A thin, lighted tube called an endoscope is placed in the mouth or nose to get a closer look at the inside of your head and throat. The examination may be viewed on a computer monitor and photos may be taken to document the findings.
- Imaging tests. Imaging tests – such as X-rays, computerized tomography (CT) scan, magnetic resonance imaging (MRI) or PET/CT scans – may be ordered to get a closer look at various tissues in your body.
Your healthcare provider may use other diagnostic tests to find out more about your cancer, where it’s located and which treatments are likely to be most effective. He or she may use some of these tests to find out how well your treatment is working. Your doctor may also ask you to seek other specialists who focus their practices on diseases of the head and neck.
Stages
If you’re diagnosed with head and neck cancer, the next step will be for your oncologist (cancer doctor) to determine how advanced the cancer is. This process is called “staging.” The earliest stage cancer is called stage I (1) and the most advanced cancer is stage IV (4).
In most cases, doctors also use the T-N-M system for staging head and neck cancer:
- T describes how large and deep the primary tumor has grown, and if it has spread into nearby tissues.
- N indicates whether cancer has spread to the regional lymph nodes near the head and neck. Lymph nodes are small collections of immune system cells to which cancers commonly spread.
- M indicates if the cancer has metastasized (spread) to other distant body areas, such as the liver, lungs or bone.
Treatment options
Chapter 3
Treatment options for head and neck cancer
The type of head and neck cancer treatment your care team recommends will depend on its stage, if the cancer has spread to other parts of your body, your general health and personal preferences. Depending on your exact situation, your care team may recommend one or a combination of the following treatment options:
- Surgery. We work with expert teams of surgeons who are specially trained in the removal of cancerous and benign (non-cancerous) tumors in the head and neck. Your surgeon may also recommend the removal of the regional lymph nodes if they suspect that the cancer has spread. In some cases, you may need to undergo reconstructive surgery and/or speech therapy after surgery, as it may affect your appearance and your ability to chew, talk or swallow.
There are many different surgical procedures to treat head and neck cancer dependent on the primary site and stage of the disease:- Glossectomy (removal of the tongue). For cancer of the tongue, your surgeon may recommend this treatment. A partial glossectomy is employed for smaller cancers and removes part – less than a third – of the tongue. A total glossectomy is reserved for larger cancers and removes the entire tongue.
- Mandibulectomy (removal of the jawbone). If a tumor has grown into the jawbone, your surgeon may perform a mandibulectomy (also known as a mandibular resection). This procedure involves the removal of all or part of the jawbone (mandible). If the cancer has not spread to the jawbone, only a small portion of the bone may need to be removed. This procedure is called a partial-thickness mandibular resection or marginal mandibulectomy.
- Maxillectomy. If the cancer has grown into the hard palate (front part of the roof of the mouth), your surgeon may recommend a maxillectomy or partial maxillectomy. During this procedure, the surgeon will remove all or part of the involved bone (maxilla). Your specialist may fit you for a special denture – or prosthesis – to fill the hole in the roof of your mouth following surgery.
- Laryngectomy (removal of the voice box). In some instances, your surgeon may need to remove one of the two vocal cords (partial laryngectomy) or both vocal cords (total laryngectomy) to take out the cancer. Following removal of the larynx a stoma (hole) is made in the skin of the throat to allow air to enter the trachea (windpipe). This procedure is called a tracheotomy. It allows you to breathe and cough through the stoma, instead of through the mouth or nose.
- Laser surgery. Laser surgery involves the insertion of an endoscope with a high-intensity laser tip into the mouth or throat. The endoscope vaporizes or cuts out the tumor.
- Transoral robotic surgery (TORS). During transoral robotic surgery, your surgeon uses a computer-enhanced system to guide surgical tools to remove mouth and throat cancers. By using a robotic system, your surgeon can make more precise movements in small spaces and work around corners. This type of surgery usually leads to a faster recovery with fewer complications.
- Neck dissection. Some head and neck cancers may spread to the lymph nodes in the neck or have a high potential for that spread. These lymph nodes may require removal to determine if the cancer has spread or to remove cancer that has already spread. Neck dissections may be performed at the time of an initial surgical procedure or at a later date.
There are various types of neck dissection procedures depending on how much tissue the surgeon must remove from the neck. In a partial or selection neck dissection, your surgeon removes only a few lymph nodes. In a modified radical neck dissection, your surgeon removes most lymph nodes on one side of your neck between the jawbone and collar bone – along with some muscle and nerve tissue. With a radical neck dissection, your surgeon removes nearly all nodes on one side of the neck, as well as some muscles, nerves and veins.
- Radiation therapy. Radiation therapy kills cancer cells. At GenesisCare, our head and neck cancer treatments primarily include external beam radiation therapy (EBRT), in which a device from outside the body delivers radiation. In certain selected instances we may also employ internally placed radiation sources (brachytherapy) in which a radiation source is implanted directly within the tumor tissue.
EBRT radiation therapy for head and neck cancer includes:- Intensity-modulated radiation therapy (IMRT). IMRT uses advanced computer-assisted technology to precisely shape the radiation around your tumor, while limiting exposure to surrounding healthy tissues. IMRT is performed with a machine called a medical linear accelerator, or a LINAC.
- Hyperfractionated radiation therapy. In some instances, it may be appropriate to treat head and neck cancer in more frequent and smaller doses of radiation. Hyperfractionated radiation is typically administered twice a day instead of the more common once-a-day approach.
- Brachytherapy. This internally administered radiation therapy delivers radioactive pellets or wires to the tumor site through small plastic tubes called catheters or directly into the tissue. Brachytherapy may be used in conjunction with EBRT for early-stage tumors of the lips or mouth. There are two different types of brachytherapy employed for head and neck cancer:
- High-dose rate (HDR) brachytherapy. This is usually completed in one session with the radioactive sources removed after each treatment.
- Low-dose rate (LDR) brachytherapy. The radioactive sources remain in the body until they diminish on their own.
- Chemotherapy. Chemotherapy refers to drugs that may have the ability to destroy cancer cells. Our expert teams may recommend chemotherapy before, during or after other treatments, or on its own. Your head and neck cancer care team may also recommend combining chemotherapy with radiation therapy (chemoradiation) before or after surgery.
The type of chemotherapy you may receive will depend on the location, stage and tissue type of your head and neck cancer. If you have head and neck cancer that has spread to other parts of your body, chemotherapy may help control its growth, relieve symptoms and improve your head and neck cancer prognosis. - Targeted therapy As we have learned more about head and neck cancer, new treatments that can specifically target it have been developed. We sometimes use targeted therapy to seek and attack cellular activity that the cancer needs to survive and grow. Your head and neck cancer care team may use targeted therapy depending on the specific genetic makeup of your cancer. The main type of targeted therapy for head and neck cancer is a monoclonal antibody that targets a protein on the surface of the cells in the oral cavity and may be an effective head and neck cancer treatment. By interfering with the protein, the cells can no longer grow and divide – which slows or even stops the cancer’s growth.
- Immunotherapy. Immunotherapy helps your body’s own immune system to recognize and fight cancer. Checkpoint inhibitors are effective immunotherapy against some head and neck cancers. These work by blocking the signals that stop the immune system from attacking the head and neck cancer cells.
Drain education
Chapter 4
Drain education
Drains have been placed in the neck to help you heal from surgery. Please see below for general instructions on how to care for your drains. If you have any questions or concerns, please contact our office.
- Wash your hands with soap and water after the drain is emptied.
- Firmly hold the tubing near your skin so you don’t pull out the drain. Pinch the tube with your other hand and slide your fingers down towards the drain bulb.
Your care team will advise if you need to repeat this step more frequently throughout the day to avoid any clotting in the drains. - Open the cap on the drain and empty the liquid into the cup provided by your care team.
- Write down the amount of fluid drained (in milliliters), which drain the fluid came from, and what color the drainage was.
- Compress (squish) the bulb and then replace the cap on the drain. The drain must be compressed to work properly.
- After you have recorded the drainage information, you may discard the drained fluid down the sink or toilet.
- In general, drains should be emptied at least twice daily, and more as needed. Your care team will advise how often your drains should be emptied.
- Contact your care team immediately if you have an increase in drainage from your drains, or there is a change in color.
PEG-tube education
Chapter 5
PEG-tube education
When undergoing surgery or radiation therapy for head and neck cancers, your ability to maintain a healthy diet and weight is crucial. However, treatment can often cause side effects that impact swallowing, taste and eating. In these cases, your care team may recommend you get a percutaneous endoscopic gastrostomy tube to maintain your nutrition. Better known as a PEG tube, this is a tube that can provide food, liquids and medications directly into your stomach.
A gastroenterologist, surgeon or interventional radiologist will be able to insert a PEG tube, and our team can help provide recommendations for local providers to refer you to.
How to feed yourself with a PEG tube
- Thoroughly wash your hands with soap and water.
- Flush your PEG tube prior to inserting any nutritional supplement. Typically, it is recommended that you flush the tube with 30 to 60 mL of warm water, but your gastroenterology team can provide specifics for your individual needs.
Make sure that your tube is clamped before opening the port. Place the syringe firmly into the port before opening the clamp to flush the tube. - While sitting upright, insert the syringe into the feeding port of the PEG tube. Push the syringe plunger gently down to administer the nutritional supplement.
- Once all nutrition has been received through the tube, it is recommended that you again flush the tube with 30 to 60 mL of warm water.
Make sure that you clamp the tube before disconnecting the syringe. - Dispose of anything that is not marked as washable and reusable.
- Wash your hands again with soap and water.
- Remain sitting or standing upright for 60 minutes after administering a feeding. It is important that you do not lay down for an hour after your feeding as it increases the risk of aspiration, which is where liquid can come up from your stomach and enter your lungs, causing pneumonia.
How to care for your PEG tube
- Check your PEG tube daily:
Make sure the bumper, or the plastic disc, is right up against your skin. Contact the team that inserted the tube if the disc feels tighter or looser than normal.
Make sure that the length of the tube is the same as it has been, and not getting longer or shorter. Contact the team that inserted the tube if you notice any changes with the tubing. - Change the dressing behind the bumper as instructed by the team that inserted the PEG tube. In many cases, it will be recommended that these dressings are changed daily. Be careful not to force the dressing into place.
- Clean the skin around the PEG tube gently each day with soap and water. Do not use hydrogen peroxide or any cleansers not approved by the team that inserted the PEG tube.
- Tape the tube down to your skin to avoid it being tugged at or breaking down the skin.
Other things you should know
- Having a PEG tube in place doesn’t mean you are not able to eat or drink small amounts of food and beverage by mouth. Talk to the team who inserted the tube about how much you can feed yourself orally and any restrictions you should follow.
- Continue to practice good oral hygiene even if you are not consuming food by mouth. Make sure you are brushing and flossing your teeth regularly. Additionally, there are also special swabs that can be used to keep the mouth clean and moist.
- Most liquid medication can be administered by your PEG tube. However, talk to your gastroenterologist before giving yourself any new medications through your PEG tube.
- PEG tubes can be used for a few months to a few years. If a replacement tube is needed, the provider who inserted the tube can help change it for a new one.
- As your mouth and throat symptoms improve, your PEG tube management team will recommend additional nutrition by mouth. During this period of increased oral intake, the PEG tube may remain in place but not be used regularly. When you are eating a more normal oral intake regularly, the tube may be removed.
It is important that you still keep up daily hygiene and flushing of the tube even when you are not using it, until it can be removed.
Please contact the team who inserted your PEG tube if you have any questions or concerns.
Our provider
Fort Myers Surgical Oncology
4571 Colonial Blvd., Suite 210
Fort Myers, FL 33966
Call: 239-790-3480
Provider
Scott Larson, MD, Otolaryngologist at Head & Neck Surgical Cancer Specialists of SW Florida, has undergone extensive training to offer TORS and recently performed the first TORS procedure in Southwest Florida.
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